You can determine if the upload process is using an active virus scanner using the following GET:
http://[host]/[server]/api/v2/FileMgmt/InlineVirusScannersAvailable.
The response contains a Boolean value indicating if a virus scanner is currently active.
{
"@odata.context": "http://[host]/[server]/api/v2/$metadata#Edm.Boolean",
"value": false
}