A skewed, or non-orthogonal, pipe is one that does not run in one of the principle directions (N-S, E-W, U-D). Since Smart Isometrics normally constrains you to route pipe in one of these directions on the grid, special action is needed if you want to create a skewed pipe.
You can route skewed pipe using the Route 2D Skew 
and Route 3D Skew 
commands, or by holding down the CTRL key while in normal routing mode. The software
displays skewed pipe sections with their associated skew components, which are placed
automatically by the software, shown in the principle directions by dotted lines.
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At placement, the software displays skew components dotted in blue (the default sketch color), meaning their directions are known but their dimensions are not. Likewise, the software displays the skewed pipe that connects the ends of the two components in red (the default sketch color), meaning that neither the dimension nor the direction of this pipe is known. You can define sketch colors using the options on the Colors tab in the Options dialog. See Change the color of sketch status.
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You can dimension the skew using either of the following methods.
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Manually set the length of the skew components, which implies the angle for the skew.
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Use the Properties window to define the angle between the skew and the first axis (the axis order) and the overall length.
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What do you want to do?